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American Skullcap (Scutellaria lateriflora) is a North American native plant in the mint family with a long history of use in American folk medicine as a nervine — herbs that specifically act on the nervous system. Its traditional name "mad dog skullcap" comes from its historical use for neurological conditions. Modern phytochemical research has identified its primary active constituents as baicalin, baicalein, and wogonin — flavone compounds that bind to GABA-A receptors, the same receptor system modulated by benzodiazepines. Unlike pharmaceutical anxiolytics, skullcap's flavone binding is partial and selective — producing mild anxiolytic and nervous-system-calming effects without dependency, significant sedation, or cognitive impairment. Wogonin in particular has been studied for selectivity at the benzodiazepine-binding site on GABA-A receptors. Herb Pharm prepares this as an alcohol-free vegetable glycerin extract (glycerite), preserving the flavone profile while making it suitable for those avoiding alcohol. Certified organic Scutellaria lateriflora aerial parts, harvested in flower for peak flavone content.
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