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American Health Super Papaya Enzyme Plus delivers a broad-spectrum digestive enzyme blend built around two of the most well-studied plant-derived proteolytic enzymes — papain (from papaya fruit) and bromelain (from pineapple stem, not fruit: the stem contains significantly higher enzyme concentrations than the fruit flesh). Papain is a cysteine protease with an unusually wide pH activity range: it cleaves peptide bonds across a pH range of approximately 3.5–8.0, remaining active throughout the stomach and upper intestine where pancreatic enzymes don't function optimally. This broad pH tolerance means papain supports digestion throughout the full GI transit rather than only at the alkaline pH of the small intestine. Bromelain provides complementary proteolytic action but also inhibits NF-κB signaling and prostaglandin synthesis — a secondary anti-inflammatory mechanism that explains why bromelain has clinical applications beyond digestion (joint and tissue inflammation). Both enzymes are stable in chewable tablet form and begin working in the mouth, where initial food breakdown starts digestion before the stomach. Pancreatin and amylase round out the formula for fat and carbohydrate coverage. Vegetarian and gluten-free. 180 chewable tablets. No artificial colors, flavors, or preservatives. From American Health.
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