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George's Herbal Rubdown combines aloe vera with a warming herbal blend for topical relief of minor muscle and joint discomfort. The aloe vera base provides more than carrier function: the polysaccharide acemannan (acetylated mannose) in aloe gel inhibits bradykinin (a peptide that sensitizes pain receptors and promotes inflammation), which is the mechanism behind aloe's soothing action on irritated or inflamed tissue. Acemannan also stimulates fibroblast proliferation, which supports tissue recovery. The warming botanicals in the blend create what pharmacologists call a counterirritant effect — sensory compounds (typically containing menthol, camphor, or capsaicin analogues) activate specific thermoreceptor channels in the skin (TRPM8 for cold/menthol, TRPV1 for heat/capsaicin), generating competing sensory input that, via gate control theory of pain modulation, suppresses pain signal transmission in the dorsal horn of the spinal cord. This is the mechanism behind the "warming" sensation that temporarily overrides underlying ache. Massage application further promotes local circulation. 8 fl oz. For external use only.
Apply liberally to affected muscles or joints and massage gently until absorbed. May be used several times daily as needed. For external use only — avoid contact with eyes and open wounds.
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